Friday, May 24, 2013

'Extremely Active' Atlantic Hurricane Season Predicted

Hurricane Sandy churns off the Atlantic coast on Oct. 29. NOAA officials are forecasting seven to 11 hurricanes, compared with about six in a typical season.

NASA/Getty Images

Unusually warm ocean temperatures and favorable wind patterns mean the Atlantic is likely to see "an active or extremely active" hurricane season this year, say officials from the National Oceanic and Atmospheric Administration.

The agency expects between seven and 11 hurricanes and as many as 20 named storms during the 2013 season, which runs from June 1 through November.

So for residents of the Atlantic and Gulf coasts, "now is the time to pay attention to preparedness," NOAA's acting administrator, Kathryn Sullivan, told a news conference Thursday at the agency's new Climate Prediction Center in College Park, Md.

Extreme weather can be deadly, Sullivan and other officials at the event stressed. "Our hearts go out to the people in the communities in Oklahoma, who as we join here today to talk about hurricanes, are still recovering from Monday and Tuesday's devastating tornadoes," Sullivan said.

Tornadoes, like the one that ripped through Moore, Okla., can produce winds that are more intense than those of hurricanes. But hurricanes generally cause more damage and loss of life because they can cut a swath of destruction that is hundreds of miles across.

In an average year, about six hurricanes and 12 named storms form in the Atlantic Ocean and Caribbean Sea. But this year is likely to be more active than normal for at least two reasons, say forecasters.

One reason has to do with the temperature of the water where hurricanes tend to form. "The tropical Atlantic is very warm, much warmer than normal," says Phil Klotzbach of Colorado State University. "And since hurricanes live off of warm ocean water, we expect to see more tropical cyclones and probably more intense [ones] than an average season."

Another factor is the lack of so-called El Nino conditions, which occur when waters in the tropical Pacific heat up. An El Nino tends to produce wind patterns that tear apart Atlantic hurricanes as they approach the U.S.

Last year at this time, many forecasters believed an El Nino was on the way, says Dan Leonard of Weather Services International. "And then in reality, El Nino wasn't as strong as we initially thought."

So there were lots of storms, including 10 hurricanes. But most of them turned away from the East Coast as they encountered strong winds from the jet stream, Leonard says.

Government forecasters say it's hard to know whether those winds will continue in 2013. But Leonard says he sees some evidence that they will.

"We think we'll have a pretty active jet stream, and that should deflect a lot of these storms back out to sea," he says, adding "that's not to say that one can't sneak through as we saw happen last year with Sandy."

Sandy struck the New York and New Jersey coast in late October and became the second-costliest hurricane in U.S. history. At the NOAA news conference, Sullivan urged people to think back to that storm as they prepare for the upcoming season.

"With the devastation of Superstorm Sandy fresh in our minds and another active season forecast," Sullivan said, "we again encourage families and businesses in states along the Gulf and Atlantic Coast and inland from those areas to take time now to make or refresh their hurricane preparedness plans."

Source: http://www.npr.org/2013/05/23/186236171/extremely-active-atlantic-hurricane-season-predicted?ft=1&f=1007

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CT detects twice as many lung cancers as X-ray

May 22, 2013 ? Physicians have more information to share with their patients about the benefits and risks of LDCT lung cancer screening following today's publication in the New England Journal of Medicine of the results of the first (of three planned) annual screening examinations from the NLST. "For a cancer screening to work, it's important to verify that it can in fact discover cancers early. The analysis of NLST participants' initial annual screening examination provides evidence that the number of early-stage cancers detected in the trial's CT arm were significantly greater than the number detected in the chest X-ray arm," says Timothy Church, Ph.D., a biostatistician and professor in the School of Public Health at the University of Minnesota who has been involved with the NLST's design, implementation and analysis.

Church also points out that a reduction in mortality is the ultimate indicator of a successful cancer screening strategy. The NLST is a large-scale, longitudinal clinical trial that randomized over 53,400 study participants equally into either the LDCT or standard CXR arm to evaluate whether lung cancer screening saves lives. Published results (NEJM; 2011) reported a 20 percent reduction in lung cancer deaths among study participants (all at high risk for the disease) screened with LDCT versus those screened with CXR.

The authors report that the NLST initial-screening results are reflective of other large trials with regard to positive LDCT versus CXR results, with more positive screening exams [7191 vs. 2387, respectively], more diagnostic procedures [6369 vs. 2176, respectively], more biopsies and other invasive procedures [297 vs. 121, respectively], and more lung cancers seen in the LDCT arm than in the CXR arm during the first screening round of NLST [292 vs. 190, respectively]. Although these results were generally anticipated, a key reason to publish the data was to document the exact differences between the two arms. "Although we did see that CT resulted in referring more patients for additional testing, the question comes down to whether the 20 percent reduction in mortality is worth the additional morbidity introduced by screening high-risk patients," says Church. He notes that although there were more follow-up procedures in the LDCT versus the CXR arm, it was encouraging to confirm that the number of individuals who actually had a more invasive follow-up procedure was quite small.

Another encouraging result reported is the high rate of compliance in performing the LDCT examination as specified in the research protocol across the 33 imaging facilities that carried out the study. "The sites complied with the low-dose CT imaging protocol specifications in 98.5 percent of all studies performed, which is outstanding considering the many thousands of scans performed," states Denise R. Aberle, M.D., the national principal investigator for NLST ACRIN and site co-principal investigator for the UCLA NLST team. Aberle, a member of the UCLA Jonsson Comprehensive Cancer Center, professor of Radiology and Bioengineering and vice chair for Research in Radiology at UCLA, also emphasizes that the first-screen result strongly suggests that CT lung cancer screening programs with radiologists who possess similar expertise and interpret similar numbers of CT cases that are obtained on scanners of the same caliber or better as those required for the NLST are likely to have results similar to those reported in the paper.

"What we've learned from the analysis of the first-screen results provides clinicians additional facts to discuss with patients who share similar characteristics as the NLST participants (current or former heavy smokers over the age of 55)," says Church. "The results also caution against making blanket lung cancer screening recommendations, because each person's trade-off between the risk of having an unnecessary procedure and the fear of dying of lung cancer is uniquely individual."

"Today's publication represents the type of immensely important data NLST will continue to provide about lung cancer screening in the United States," says Mitchell J. Schnall, M.D., Ph.D., ACRIN Network Chair, group co-chair of the ECOG-ACRIN Cancer Research Group and chair of the Radiology Department of the University of Pennsylvania. "I congratulate the NLST team on its ongoing effort to continue to mine information from the NLST trial to help guide patient, clinician and health care policy decisions."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/1Hx2zswTmVQ/130522180105.htm

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Jennifer Aniston strips in new movie trailer

Celebs

1 hour ago

One of your 1990s "Friends" just got a heckuva lot more friendly. In the new trailer for her upcoming movie "We're the Millers," Jennifer Aniston plays a stripper who agrees to pretend to be a suburban mom to help Jason Sudeikis smuggle marijuana into the U.S. from Mexico.

And Aniston seems to have her character's job down pat. She's seen sashaying around a stripper pole and giving Sudeikis a lap dance while wearing a platinum wig and black lingerie.

In the plot, Sudeikis is roped into a deal by rich guy Ed Helms -- who owns his own orca! -- and agrees to enlist a fake family and drive an RV across the Mexican border to pick up the pot. The hope is that a friendly looking family won't invite suspicion at the border crossing, and Sudeikis also enlists a sullen runaway (Emma Roberts) and a geeky neighbor boy (Will Poulter) to pretend to be his kids.

Of course, it doesn't quite work out. Later in the film, thefake family is confronted by armed drug dealers. Aniston then strips down to peach lingerie and gyratesto Mickey Avalon's "Stroke Me" to prove she's really a stripper and not a soccer mom. She's got all the right moves, and somewhere back in the 1990s, Ross Geller is passing out from shock.

Aniston and her "Friends" also made the news this week when the actress and former co-stars Courteney Cox and Matthew Perry joked about a possible reunion in a skit for "The Ellen DeGeneres Show."

"We're the Millers" hits theaters Aug. 9.

Source: http://www.today.com/entertainment/pole-dancing-princess-jennifer-aniston-strips-new-movie-trailer-6C10037833

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Thursday, May 23, 2013

MetLife on track for 500 jobs in Charlotte this year

NANCY PIERCE

Eric Steigerwalt, MetLife Inc. executive vice president, spoke to the Charlotte Business Journal in an interview this spring.

MetLife Inc. plans to have 500 workers on the ground in Charlotte by the end of this year.

Executive Vice President Eric Steigerwalt, the insurer's head of U.S. retail, provided the target to investors in a conference on Tuesday. Steigerwalt will lead the new retail headquarters that's moving to Ballantyne Corporate Park. He and his entire management team will relocate to Charlotte this summer, he says. Read more about Steigerwalt from my sit-down with him earlier this spring.

During his presentation, Steigerwalt said he was pleased with how the company's employees across the country have reacted to the news that the retail business will consolidate in Charlotte. He said in addition to the 500 employees this year, MetLife plans to have 800 more workers on site in Charlotte by the end of 2014.

He says the Charlotte operation will replace 10 other sites where retail employees are based.

After my colleague Will Boye broke the story in February, MetLife in March announced it would relocate more than 1,300 jobs here and create a headquarters for its U.S. retail insurance and annuity business. We've also reported MetLife is eyeing Charlotte for even more expansion over time.

Steigerwalt says the relocation will allow his team to develop a thriving company culture here that can lead to improved results. "In addition, we're going to save a lot of money through this move," he said Tuesday.

Cost savings are a big focus for the retail business at MetLife this year. Steigerwalt says the company intends to save $150 million in net cost-cutting. It is accomplishing that through the move, a reduction in less-productive advisers (shrinking to 5,000 from 7,500 a year ago by instituting minimum production standards) and by restructuring third-party sales agreements. MetLife also is retooling some of its annuities and life insurance products to reduce cost and risk.

"Our productivity is up and we're making a lot more money," Steigerwalt said Tuesday. "We're putting all of our resources into people who are doing a great job for their clients and for our company."

Adam O'Daniel covers banking, entrepreneurs and technology for the Charlotte Business Journal.

Source: http://feedproxy.google.com/~r/bizj_charlotte/~3/n-7_m_0o830/metlife-on-track-for-500-jobs-in.html

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How gold nanoparticles can help fight ovarian cancer

May 21, 2013 ? Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Mayo Clinic researchers found out why and determined how to make the nanoparticles effective against ovarian cancer cells.

The discovery is detailed in the current online issue of the Journal of Biological Chemistry.

"This study identifies a novel mechanism that protects ovarian cancer cells by preventing the cell death or apoptosis which should occur when they encounter positively charged nanoparticles," say the senior authors of this study, Priyabrata Mukherjee, Ph.D., a Mayo Clinic molecular biologist, and Y. S. Prakash, M.D., Ph.D., a Mayo Clinic anesthesiologist and physiologist.

Why Cancer Cells Survived

Gold nanoparticles can have many medical uses, from imaging and aiding diagnoses to delivering therapies. In this case, using a special preparation to put positive ionic charges on the surface, the nanoparticle is intended to act as a targeted destructor of tumor cells while leaving healthy cells alone. The nanoparticles are supposed to kill cells by causing cellular calcium ion levels to increase. But researchers discovered that a regulatory protein in the mitochondria essentially buffers the rising calcium by transporting it into the mitochondria, thus subverting cell death. Cancer cells have an abundance of this transporter and may thus be protected from nanoparticle toxicity. The research team discovered that if they inhibit calcium uptake into the mitochondria, sufficient cellular stress builds up, making the gold nanoparticles more effective in destroying cancer cells.

The researchers say that understanding how mitochondrial transport mechanisms work will help in the design of targeted therapies against cancer. They called for nanoparticle developers to integrate this new mechanistic knowledge into their processes for designing nanoparticle properties to be used in therapy.

The study was a team effort between researchers at Mayo Clinic including Mayo authors Rochelle Arvizo, Ph.D., Sounik Saha, Ph.D., Michael Thompson, and Resham Bhattacharya, Ph.D.; and the University of Massachusetts at Amherst including Daniel Moyano and Vincent Rotello, Ph.D.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/chIQHGu7bxQ/130521105059.htm

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The World's Ten Largest Engines

What's the largest engine in the world? Well, it depends from how you look at it. Thankfully, we have dedicated Jalopnik readers to help us finding the right answers.

So here we go, with everything from heavy oil burning monsters to steam turbines and some renewable energy thrown in for good measure.


10.) The Largest Production Motorcycle Engine

How big: 2.3 liters
How powerful: 140 horsepower

You would expect this trophy to land at an American company like Harley Davidson, and yes, Boss Hoss Cycles indeed makes choppers powered by GM small- and big block crate engines. If you don't think a Chevy big block crammed into a bike counts, the largest "proper" motorcycle engine is the British Triumph Rocket III's water-cooled three-cylinder producing 150 lb?ft of torque.

Suggested By: 472CID, Photo Credit: Wikipedia


9.) The Largest Current Production Car Engine

How big: 8.4 liters
How powerful: 640 horsepower

Congratulations Chrysler! Nobody else is crazy enough to put a 8.4-liter V10 into a production vehicle, but you've done it again. Naturally, General Motors comes to the rescue if you need even more, with the Chevrolet "572" 9.2 V8 crate engine.

Suggested By: in a mini let them mock me, as I dragon it, Photo Credit: saebaryo


8.) The Largest Radial Aero Engine

How big: 127 liters
How powerful: 5,000 horsepower

Say hi to the Lycoming XR-7755! Gamecat235 knows what happened to this baby:

It was meant for the B-36, but after they produced two, it was dropped in favor for a different design. I almost included it in my B-36 write up, but decided against it as it was just one more esoteric fact.

Make sure to read his full story.

Suggested By: Gamecat235, Photo Credit: Consolidated Aircraft Corporation


7.) The Largest Wind Motor

How big: 505 feet in diameter
How powerful: 8,046 horsepower

Siemens makes almost everything in connection with electricity, but the SWT-6.0-154 must be one of their largest products yet. It also keeps pandas alive, sort of. Read all about it here!

Suggested By: BigHarv, Photo Credit: Siemens AG


6.) The Largest (By Length) Steam Locomotive Engine

How big: 85 feet 3.4 inches long
How powerful: tractive effort was 135,375 lbf (11,281 ft-lb)

Union Pacific Railroad's 4000-class 4-8-8-4 articulated steam locomotives, commonly known as the 'Big Boys' were built between 1941 and 1945. 25 went into service, with the last ride ending in 1959. By that time, diesel power replaced steam, bu.

Suggested By: f86sabre, Photo Credit:hugh llewelyn


5.) The Largest Locomotive Engine

How big: 83 feet 6.5 inches long
How powerful: 4,500-8,500 horsepower (3rd. generation)

I can't explain the "Big Blow" better than Union Pacific themselves:

It was very inefficient and used highly sensitive fuel oil and there are stories of them melting bridges when parked running on top of them. The last ride was in 1969.

Suggested By: My X-type is too a real Jaguar, Photo Credit: Wikipedia 1,2.


4.) The Largest Industrial Turbine Engine

How big: You will need a nuclear power station to hold it
How powerful: 2,346,788 horsepower

This is the 1750 MWe ARABELLE turbine generator, which converts wet steam from a French nuclear generator into electricity. The blades alone weigh 176 pounds. That's a lot of rotors from the French.

Suggested By: wankelwanker and BigHarv, Photo Credit: Alstrom


3.) The Largest Rocket Engine

How big: 18.5-feet for the engine, 363 feet tall with the full rocket
How powerful: 190 million horsepower

When you want to go to the moon, you need a big engine. The Saturn V was the biggest they ever made.

Suggested By: John Coctostan and f86sabre, Photo Credit: Boeing


2.) The Largest Car Engine Of All Time

How big: 28.3 liters
How powerful: 300 horsepower

Yes, there are some cars with larger airplane engines out there, but this Fiat is the real deal. According to Team DAN, this is what you need to know:

Built in the winter of 1910/11 by Fiat to take on the Blitzen Benz, it featured a four cylinde 28.3 litre engine (190x250mm). Two of these cars were built. Number 1 was purchased by the Russian Prince Boris Soukhanov late 1911, but after the Russian revolution it went to Australia where it was fitted with a Stutz engine until it was crashed in 1924. Number 2 was retained by Fiat, but was scrapped in 1920, only the engine being kept.

Suggested By: TheBaron2112, Photo Credit: Fiat


1.) The Largest Marine Engine

How big: 89 feet long and 44 feet wide, 1,820 liters per cylinder, 10,920 to 25,480 liters total
How powerful: 107,389 horsepower

The Finnish W?rtsil?-Sulzer RTA96-C powers the largest vessels in the world. It's a two-stroke turbo running on heavy fuel oil and it can be configured with six to fourteen cylinders. Brian, The Life of had this to add:

Consuming more than 39 barrels of oil per hour, it costs $34/minute to run. Wow!

Wow indeed!

Suggested By: Brian, The Life of , Photo Credit: W?rtsil?

Welcome back to Answers of the Day - our daily Jalopnik feature where we take the best ten responses from the previous day's Question of the Day and shine it up to show off. It's by you and for you, the Jalopnik readers. Enjoy!

Top Photo Credit: NASA via Bryan K

Source: http://jalopnik.com/the-worlds-ten-largest-engines-509258535

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Housing recovery boosts Home Depot results; outlook raised

By Dhanya Skariachan

(Reuters) - Home Depot Inc reported higher-than-expected quarterly results and raised its sales and profit outlook for the year on Tuesday as the world's largest home improvement chain benefited from a nascent recovery in the U.S. housing market.

The news pushed the retailer's shares up as much as 3.4 percent to an all-time high and gave fresh evidence that the U.S. housing market was improving after years of weakness.

For the first time since 2008, sales to contractors and professional customers grew at a faster pace than those to regular homeowners and other shoppers, Chief Executive Officer Frank Blake said on a conference call.

"This quarter's outperformance from the pro segment is a positive sign" of a housing recovery, Blake said.

A bubble in the U.S. housing market was at the core of the 2007-2009 financial crisis. During the downturn, Home Depot's sales at established stores fell more than 20 percent in such markets as Florida and California. In recent quarters, the company has gotten a boost as housing markets have rebounded in regions where it has a heavy presence.

"In the first quarter, we saw less favorable weather compared to last year, but we continue to see benefit from a recovering housing market that drove a stronger-than-expected start to the year for our business," Blake said.

Recent government data showed permits for single-family homes rose 3 percent to 617,000 in April, the highest since May 2008, while newly issued building permits, a gauge of future construction, rose 14.3 percent.

SALES STRENGTH

Despite cooler-than-usual weather in many parts of the United States at the start of the spring selling season, Home Depot's sales rose 7.4 percent to $19.12 billion in the first quarter ended on May 5. That topped the analysts' average estimate of $18.68 billion.

Better pricing and customer service have helped Home Depot take market share from smaller rival Lowe's Cos . The industry leader has also gained from tailoring its marketing to local areas, centralizing distribution centers and shifting more workers to jobs where they serve customers directly.

Sales at Home Depot stores open at least a year rose 4.3 percent, including a 4.8 percent increase in the United States. Many on Wall Street expect same-store sales at Lowe's to be weaker than Home Depot's for the 16th straight quarter when the smaller chain reports results on Wednesday.

Credit Suisse analyst Gary Balter said he expected Home Depot's sales to accelerate this year "given the company's strong internal momentum and a developing external tailwind in housing." He has an "outperform" rating on the stock.

At the end of 2012, Home Depot had 19 percent of the U.S. home improvement retail market and Lowe's had 16.7 percent, data from Euromonitor International showed. (Related graphic: http://link.reuters.com/teh38t)

Under Blake, Home Depot was quicker than Lowe's to cut costs in the years after the housing collapse.

Net income in the first quarter rose to $1.2 billion, or 83 cents a share, from $1 billion, or 68 cents a share, a year earlier. Analysts on average had forecast a profit of 77 cents a share, according to Thomson Reuters I/B/E/S.

For the year, the company now expects earnings of $3.52 a share, up from its prior outlook of $3.37. It forecast a sales increase of about 2.8 percent, up from previous expectations of a 2 percent rise.

Shares of Home Depot were up 2.8 percent at $78.89 in morning trading after rising as high as $79.40 earlier in the session.

(Reporting by Dhanya Skariachan; Editing by Lisa Von Ahn)

Source: http://news.yahoo.com/home-depot-quarterly-profit-sales-rise-102221949.html

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