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Public release date: 3-Jun-2013[ | E-mail |
Share ] Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
The immune system can run awry in many ways. Some examples of undesirable immune responses include those directed against the host (autoimmunity), transplanted organs (transplant rejection), or a harmless substance (allergies). In each case, the immune system is reacting to the presence of a molecule known as an antigen. Currently, the best treatment options involve broad spectrum suppression of the immune system, which increases susceptibility to infection. A preferable solution would be to specifically turn off the immune cells that respond to non-threatening objects.
In this issue of the Journal of Clinical Investigation, Dr. James Paulson and colleagues at The Scripps Research Institute in La Jolla, California used antigen-decorated nanoparticles to block the development of antibodies to a immune response-inducing antigens in mice. In an accompanying commentary, Edward Clark of the University of Washington discusses how this finding could lead to therapeutic agents capable of precisely controlling our immune system, allowing favorable responses and inhibiting unfavorable responses.
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TITLE: Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis
AUTHOR CONTACT:
James C Paulson
The Scripps Research Institute, La Jolla, CA, USA
Phone: 858-784-9634; Fax: 858-784-9690; E-mail: jpaulson@scripps.edu
View this article at: http://www.jci.org/articles/view/69187?key=d3ac5675f0e4224288c1
ACCOMPANYING COMMENTARY
TITLE: STALing B cell responses with CD22
AUTHOR CONTACT:
Edward A Clark
University of Washington, Seattle, WA, USA
Phone: 206 543-8706; E-mail: Eclark@wanprc.org
View this article at: http://www.jci.org/articles/view/69670?key=0b5f09cda9a91d9896b6
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 3-Jun-2013[ | E-mail |
Share ] Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
The immune system can run awry in many ways. Some examples of undesirable immune responses include those directed against the host (autoimmunity), transplanted organs (transplant rejection), or a harmless substance (allergies). In each case, the immune system is reacting to the presence of a molecule known as an antigen. Currently, the best treatment options involve broad spectrum suppression of the immune system, which increases susceptibility to infection. A preferable solution would be to specifically turn off the immune cells that respond to non-threatening objects.
In this issue of the Journal of Clinical Investigation, Dr. James Paulson and colleagues at The Scripps Research Institute in La Jolla, California used antigen-decorated nanoparticles to block the development of antibodies to a immune response-inducing antigens in mice. In an accompanying commentary, Edward Clark of the University of Washington discusses how this finding could lead to therapeutic agents capable of precisely controlling our immune system, allowing favorable responses and inhibiting unfavorable responses.
###
TITLE: Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis
AUTHOR CONTACT:
James C Paulson
The Scripps Research Institute, La Jolla, CA, USA
Phone: 858-784-9634; Fax: 858-784-9690; E-mail: jpaulson@scripps.edu
View this article at: http://www.jci.org/articles/view/69187?key=d3ac5675f0e4224288c1
ACCOMPANYING COMMENTARY
TITLE: STALing B cell responses with CD22
AUTHOR CONTACT:
Edward A Clark
University of Washington, Seattle, WA, USA
Phone: 206 543-8706; E-mail: Eclark@wanprc.org
View this article at: http://www.jci.org/articles/view/69670?key=0b5f09cda9a91d9896b6
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-06/joci-pai052413.php
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